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- _5 wasQuotedFrom 13130303 provenance.
- _5 value "PTEN loss of function and EGFR gain of function are commonly observed in primary GBM, and are known to increase HIF-1a levels48,49. GBMs are highly vascularized tumours that are characterized by areas of necrosis surrounded by PSEUDOPALISADING CELLS that express high levels of HIF-1a protein and VEGF mRNA." provenance.