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- _5 value "Ovarian cancer cells express CD44 isoforms that cause very strong cell adhesion to HA-enriched peritoneal mesothelium. The binding of HA to CD44 isoforms triggers direct \"cross-talk\" between two different tyrosine kinase (e.g. p185HER2 tyrosine kinase (5) and c-Src kinase (6))-linked signaling pathways (cell growth versus cell migration, respectively) in ovarian tumor cells. Our results indicate that HA treatment caused the recruitment of a significant amount of IQGAP1 (Fig. 1C, panel a, lane 2) into the CD44 complex (panel c, lane 2)." provenance.