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- _4 wasQuotedFrom 11358848 provenance.
- _4 value "TGF-beta1 stimulation of COLO-357, PANC-1, and IMIM-PC1 cells lead to a down-regulation of cytokeratins 8 and 19 mRNA levels in PANC-1 and IMIM-PC1 (responsive cell lines)cells and to a minor extent in COLO-357 cells. The mesenchymal differentiation marker vimentin and collagen1alpha is strongly up-regulated in all responsive cell lines. The TGF-beta1 mediated regulation of differentiation markers occurs in a time-dependent manner. In contrast, TGF-beta1 treatment failed to induce any significant change in the expression pattern of differentiation markers in cell lines with a nonfunctional TGF-beta1 signaling pathway (IMIM-PC2 and CAPAN-1). The TGF-beta1 mediated changes of gene expression were also reproducibly observed on the protein level in all responsive cell lines in multiple experiments; however, down-regulation of epithelial marker proteins was less prominent on the RNA level." provenance.