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- _5 wasQuotedFrom _4 provenance.
- _5 value "treatment of ER-positive breast cancer with an activator of PKC, such as the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate, leads to rapid down-regulation of ER, destabilization of its mRNA, and phosphorylation of the ER protein, coincident with modulation of its function" provenance.