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- _4 value "Integrins aVb3 and aVb5 are involved in bone sialoprotein-induced cancer cell adhesion, proliferation and migration. However, the function of these integrins differs so that aVb3, whose expression is suggested to be in relation to metastatic potential, participates in cell migration, whereas aVb5 is likely to facilitate cell adhesion and proliferation. 67 , 68" provenance.