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- _4 wasQuotedFrom 11676474 provenance.
- _4 value "u-PA-CAT expressed in combination with dominant negative mutant ERK construct abrogated the Urokinase-type plasminogen activator (uPA) promoter activity in PC3(AR) (AR transfected) cells. ERK dominant negative construct reduced the uPA promoter expression greater than 24-fold. Further, expression of dominant negative vectors PC4raf, CL100, and K97M for the ERK pathway reduced uPA protein expression by 75%, 82% and 57% respectively. This indicates that in MAPK pathway ERK represent a significant component in the regulation of uPA." provenance.