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- _5 wasQuotedFrom 16522789 provenance.
- _5 value "Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis. Thus, PC suppression appears to result from a primary reduction in the FoxA2 transcription factor, which subsequently results in a reduction of its cofactor HNF6." provenance.