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- _4 wasQuotedFrom 19411758 provenance.
- _4 value "We found that Bim–/– T cells had a global defect in cytokine production affecting all cytokines tested, which included IL-2, IL-4, IL-6, IL-10, IL-17A, and IFN-? (Figure 3). Consistent with these results, overexpression of Bim in EL-4 T cells significantly increased IL-2 production (Supplemental Figure 5). The defect in Bim–/– T cells appears to lie upstream of the cytokine synthesis because mRNA expression of selected cytokines (IL-2, IL-6, and IL-17A) was also significantly reduced in these cells (ELISA and QPCR)" provenance.