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- _6 value "AKT signaling exerts a strong antiapoptotic effect through the phosphorylation and inhibition of key pro-apoptotic proteins, such as BAD, MDM2 and members of the Forkhead family (del Peso et al., 1997; Biggs et al., 1999; Brunet et al., 1999; Guo et al., 1999; Kops et al., 1999; Nakae et al., 1999; Rena et al., 1999; Takaishi et al., 1999; Tang et al., 1999; Mayo and Donner, 2001; Ashcroft et al., 2002). " provenance.