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- _6 value "The Smurfs can also regulate ubiquitination and degradation of other target proteins, including the TGF-b receptor complex and the transcriptional co-repressor SnoN (Bonni et al., 2001; Ebisawa et al., 2001; Kavsak et al., 2000; Stroschein et al., 2001) (Fig. 7). Smurf1 and Smurf2 associate with the nuclear I-Smad Smad7 after stimulation by TGF-b (Ebisawa et al., 2001; Kavsak et al., 2000). The I-Smad-Smurf complex is exported to the cytoplasm and ubiquitinates the receptors on the cell surface or endosomal membranes; these are then targeted for degradation in proteasomes and lysosomes." provenance.