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- _5 wasQuotedFrom 15345710 provenance.
- _5 value "To determine whether LRIG1 expression influences the ubiquitination and degradation rate of ErbB receptors in the inducible expression system, we focused on the effect of LRIG1 expression on the properties of EGFR in the PC3-LRIG1 cells. Similar to the results with transfected 293T cells (Fig. 3), we observed that the induction of LRIG1 expression markedly augmented the ubiquitination of EGFR in response to EGF treatment (Fig. 5A). This potentiation of ligand-stimulated EGFR ubiquitination correlated with a suppression of EGFR tyrosine phosphorylation and receptor levels after growth factor treatment." provenance.