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- _4 wasQuotedFrom 11172729 provenance.
- _4 value "Two other endothelial cell-specific receptors, called Tie-1 and Tie-2 (for \"tyrosine kinase with immunoglobulin- and EGF-like domains\") have been identified several years ago. Knock-out experiments in mice have suggested a role for these receptors in blood vessel maturation. The ligands for Tie-2 have only recently been discovered: angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) both bind Tie-2, but only the binding of Ang-1 results in signal transduction and regulation of blood vessel maturation (227). Therefore, Ang-2 is a natural antagonist of Ang-1 (146)." provenance.