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- _4 wasQuotedFrom 12635173 provenance.
- _4 value "Serine 167 in AF1 is also phosphorylated, this time by the 90-kDa ribosomal S6 kinase RSK 89, which is itself activated by ERK1 and ERK2. Another signalling pathway that might have an important role in ER activity is the phosphatidylinositol- 3-OH kinase (PI3K) signalling pathway. The serine/threonine protein kinase AKT (or PKB) is one of the downstream targets of PI3K97. Its activation promotes cellular proliferation and anti-apoptotic responses. ER phosphorylation by AKT occurs at serine 167 and results in ligand-independent activation of ER98,99." provenance.