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- _3 wasQuotedFrom 18705745 provenance.
- _3 value "Classically, it is considered that the number of normal mtDNA copies must fall below 20–40% of basal levels to induce mitochondrial dysfunction and adverse events [6]. Below this threshold, hepatic mtDNA depletion can impair the MRC. This impairment can hamper the regeneration of NAD+ and FAD, thus leading to a secondary inhibition of the oxidation of fatty acids and pyruvate." provenance.