Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RANlTskcx1ucICGO8eOXp-d5m33H1T-0plS-_jL-IZHCw#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 14991903 provenance.
- _5 value "The chondrocyte cell lines C28/I2, C20/A4, and T/C28a2/a4 expressed functionally active VEGFR-2. VEGF stimulation induced receptor phosphorylation, activation of the mitogen-activated protein kinases ERK 1/2, and long-lasting activation of the transcription factor AP-1 (activator protein-1). VEGF increased secreted MMP-1, MMP-3, and especially MMP-13, which could be effectively reduced by an inhibitor of VEGFR-2 kinase activity. Interestingly, VEGF diminished the expression of TIMP-1 and especially TIMP-2." provenance.