Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAOhowc0P_Gir9ja-tqW-Zte8gWW6YWBPU69mFamvfQGg#_7> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _7 wasQuotedFrom 15021891 provenance.
- _7 value "targeted Skp2 expression to the T-lymphoid lineage markedly cooperates with the activated oncogene N-Ras. Compared to transgenic animals expressing activated N-Ras alone, Skp2 coexpression causes an acceleration in tumor onset, increased penetrance of lymphomagenesis and decreased survival rate. ectopic expression of Skp2 in nonadherent fibroblasts leads to entry into S phase, p27 downregulation and cell division, indicating that anchorage-dependent growth,a characteristic of nontransformed cells, is abrogated by Skp2 overexpression" provenance.