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- _5 wasQuotedFrom 11457849 provenance.
- _5 value "periodically stretched them for 6 h (15% elongation, 0.5 Hz). The cells responded with an increase both in ET(B)-R mRNA (12-fold compared with control) and protein (4-fold). Among various kinase pathways, Rho kinase (ROCK) and p38 mitogen-activated protein kinase (p38 MAPK) mediated part of the deformation-induced increase in ET(B)-R expression, as judged by the inhibitory effect of Y27632 (1 microm, 38% inhibition) and SB202190 (10 microm, 44% inhibition), respectively." provenance.