Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAOmZj-TlmzUmQhofXuAmdTJzbjL1FMULkgQu7zVa32NI#_8> ?p ?o ?g. }
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- _8 wasQuotedFrom 7629134 provenance.
- _8 value "Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals. Here, we show that the representative members of both families of CDK inhibitors, p21waf1,cip1, p27kip1, and p18, can prevent the phosphorylation of their CDK partners, CDK2 and CDK6, by CDK-activating kinase." provenance.