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• _2 wasQuotedFrom 11015622 provenance.
• _2 value "when administered intravenously, PAF is hypotensive in all species studied In animal species such as the rat, where platelets are insensitive to PAF action, no tachyphylaxis was observed action of PAF on the heart, peripheral vasculature, and microcirculation may account, at least in part, for the reduction of systemic blood pressure. PAF decreases the cardiac output through several mechanisms: 1) it reduces venous blood return as the consequence of peripheral vasodilatation or vasoconstriction and increased microvascular permeability; 2) it produces a right ventricular overload with an increased right atrial pressure and a reduced filling of left ventricle as the result of an increase in pulmonary vascular resistance; 3) it may impair cardiac function by a direct negative inotropic effect and by reduction of coronary blood flow (CBF); and 4) finally, PAF was shown to affect cardiac electrical activity and the conducting system. 3) it may impair cardiac function by a direct negative inotropic effect and by reduction of coronary blood flow (CBF); and 4) finally, PAF was shown to affect cardiac electrical activity and the conducting system. High doses of PAF, in contrast, produced a sustained decrease of cardiac index, tachycardic response, and transient fall followed by sustained increase of total peripheral resistances In the mesenteric district, a marked reduction of blood flow consequent to the increase in mesenteric resistance was observed (380). it was found that delayed and persistent but not early hypotension induced by PAF is inhibited by Nv-nitro-L-arginine, which inhibits the production of nitric oxide from endothelial cells, thus suggesting a role for the endothelium derived relaxing factor(406)." provenance.