Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAQU0WYk9n0NmBmELmwF55ogMokPE2C71Qh3pRPbQpKSk#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 wasQuotedFrom 15345710 provenance.
- _5 value "Here we tested whether the related human LRIG1 (also called Lig-1) protein can act as a negative regulator of EGF receptor and its relatives, ErbB2, ErbB3, and ErbB4. We observed that in co-transfected 293T cells, LRIG1 forms a complex with each of the ErbB receptors independent of growth factor binding. We further observed that co-expression of LRIG1 with EGF receptor suppresses cellular receptor levels, shortens receptor half-life, and enhances ligand-stimulated receptor ubiquitination." provenance.