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- _6 wasQuotedFrom 11172729 provenance.
- _6 value "uPA is secreted as an inactive single-chain proenzyme. Secreted pro-uPA binds to the uPA receptor (uPAR) present on many different cell types. Cleavage of pro-uPA by plasmin, Factor XIIa or cathepsin B yields the active enzyme consisting of two disulfide-linked chains (17)." provenance.