Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAQcBmrhjUxo7VLVPerbcGVjI4cUbnH_ee4U8z-RB2mrY#_8> ?p ?o ?g. }
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- _8 wasQuotedFrom 10514481 provenance.
- _8 value "Oncogenic Ras induces the transcription activity of NF-kappaB that confers cell survival. Oncogenic Ras also down-modulates the expression of Par-4, a transcriptional repressor protein, that is essential but not sufficient on its own to induce apoptosis. Here we show that reintroduction of Par-4 by transient transfection leads to apoptosis in cells expressing oncogenic Ras but not in those that lack oncogenic Ras expression. Par-4 abrogates oncogenic Ras-inducible NF-kappaB transcription activity" provenance.