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- _5 wasQuotedFrom 10436023 provenance.
- _5 value "<C31> Cyclin D:Cdk4 phosphorylates pRb at a subset of sites, P(D), but this does not suffice to abrogate the inhibition of E2F. <C32> Cyclin E:Cdk2 phosphorylates pRb at additional sites, P(E), after the Cyclin D:Cdk4-specific sites have been phosphorylated. (Cyclin E, in addition to acting on pRb, has actions that can induce S phase independent of pRb [Lukas et al., 1997; Lundberg and Weinberg, 1998].)" provenance.