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- _5 value "In SP-C/Dkk1 embryos, however, BMP4 expression is significantly reduced (Fig. 5J). As discussed above, at E12.5, the efficiency of β-catenin excision in many SP-C/rtTA:tetO-cre X β-cateninflox embryos is less than 100% in some embryos resulting in a mosaic pattern of β-catenin expression in the lung airway epithelium. However, this result proves advantageous since we can determine in a precise cell specific manner whether loss of β-catenin leads to a loss of BMP4. As expected, BMP4 and β-catenin are expressed at high levels in distal airway epithelium in wild-type lungs at E12.5 (Figs. 5K– M). Lungs exhibiting mosaic expression of β-catenin also express BMP4 in a mosaic pattern that closely correlates with presence of β-catenin (Figs. 5N–P). Complete loss of β-catenin leads to a complete loss of BMP4 expression (Figs. 5Q–S)." provenance.