Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RARcwg6o-fvU0GWvqX1vJyS7ShSGntif9qaXbqFR0kNMM#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 9328350 provenance.
- _5 value "Constitutive expression of Dlx-5 in ROS 17/2.8 cells decreased osteocalcin promoter activity in transient assays, and conditional expression of Dlx-5 in stable cell lines reduced endogenous mRNA levels. Consistent with this finding, antisense inhibition of Dlx-5 increased osteocalcin gene transcription. Osteocalcin promoter deletion analysis and binding of the in vitro translation product of Dlx-5 demonstrated that repressor activity was targeted to a single homeodomain-binding site, located in OC-Box I (-99 to -76).These findings demonstrate that Dlx-5 represses osteocalcin gene transcription." provenance.