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- _2 wasQuotedFrom 12417015 provenance.
- _2 value "Collectively, not only does Btk positively regulate PKCbI, but PKCb can negatively regulates Btk activity as a feedback loop inhibitor (Fig. 2). apparently through this mechanism, Btk positively regulates the membrane translocation and activity of PKCbI Second messengers generated by PLCg, i.e., DAG and IP3 (subsequent Ca 2+ increase), activate various PKC isoforms including the I isoform." provenance.