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- _6 wasQuotedFrom 15010462 provenance.
- _6 value "IL-6-induced Association of Gab1 and Gab2 with SHP2 Is Hck-mediated.....IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, as well as their association with SHP2, were markedly decreased in MM cells with kinase-inactive Hck versus MM cells with wild-type Hck. In anti-Grb2 immunoprecipitates, IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, but not their association with Grb2, was abrogated (Fig. 6b). Taken together, these data further confirm that IL-6-induced Gab protein tyrosine phosphorylation and formation of Gab/Grb2·SHP2-containing protein complexes is dependent on Hck activity." provenance.