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- _5 wasQuotedFrom 13130303 provenance.
- _5 value "Renal carcinoma has been of particular interest to investigators in the field, because the defining genetic lesion in RCC is loss of VHL function, resulting in high levels of HIF-1a and HIF-2a protein that are not O2 regulated.As a result, VEGF, GLUT1 and other HIF-1 target genes are constitutively expressed." provenance.