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- _5 wasQuotedFrom 19380824 provenance.
- _5 value "Maximal activation of STAT3 requires phosphorylation at both Tyr705 and Ser727 sites (14). Although JAK2 kinase is shown to be responsible for phosphorylating STAT3 at Tyr705, we have shown that IL-1 receptor associated kinase 1 (IRAK-1) is capable of selectively phosphorylating STAT3 at Ser727 (15)." provenance.