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- _3 value "FIG. 7. Effect of FLU on ADME gene expression. Fifty ADME genes found in FLU's 343-gene expression profile were agglomeratively clustered using a cosine correlation against all the compound treatments, where yellow and blue represent up- and down-regulated genes, with color saturation at +3.2- and –3.2-fold, respectively. Black arrows (right) represent dose elevation from top to bottom for each compound." provenance.