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- _4 value "Leptin receptors are members of the class 1 cytokine receptor family and are linked to JAK-STAT signalling systems. The short term regulatin of leptin expression is influenced by a number of factors that regulate CEBP alpha and PPAR gama activity on the leptin promotor. ...Insulin, glucose, and glucocorticoids induce ob (leptin) espression. while fasting, cold exposure, beta3 agonists, catecholamine stimulation and thiazolidinediones all decrease leptin expression. Leptin works to suppress appetite by affecting the synthesis and or action of a complex system of neuropeptides including neuropeptide Y, MCH, POMC, alphaMSH, all of which directly or indirectly influence food intake." provenance.