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- _5 wasQuotedFrom 12893815 provenance.
- _5 value "It has been shown recently that ubiquitination plays an important role in TAK1 activation (26, 27). IKK activation by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex composed of Ubc13 and Uev1A as well as the TAK1·kinase complex. TRAF6 can interact through its RING finger domain with Ubc13 in the Ubc13·Uev1A complex. This Ubc·TRAF6 complex catalyzes the formation of a Lys-63-linked polyubiquitin chain, which triggers TAK1 activation through a unique proteasome-independent mechanism." provenance.