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- _3 value "FoxO transcription factors promote cell cycle arrest, repair of damaged DNA, detoxification of reactive oxygen species, apoptosis and autophagy by upregulating specific gene-expression programs (Figure 1) (Brunet et al., 1999; Dijkers et al., 2000; Medema et al., 2000; Kops et al., 2002; Nemoto and Finkel, 2002; Tran et al., 2002; Lee et al., 2003; Murphy et al., 2003; Mammucari et al., 2007; Zhao et al., 2007)." provenance.