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- _5 wasQuotedFrom 16183734 provenance.
- _5 value "In parallel with the upregulation of TGF-{beta}1, the protein levels of TAK1 were significantly increased 1.66 ± 0.14-, 1.97 ± 0.16-, and 1.57 ± 0.07-fold (P < 0.01) at 1, 3, and 7 days post-MI compared with sham-operated rats (Fig. 2, A and B). Although there was no change in the protein levels of MKK3/6 and p38 MAPK levels throughout the time course, P-MKK3/6 and P-p38 MAPK were increased significantly (P-MKK3/6: 2.20 ± 0.19-, 2.55 ± 0.47-, and 3.29 ± 0.32-fold; P-p38 MAPK: 1.90 ± 0.03-, 2.03 ± 0.06-, and 2.35 ± 0.06-fold at 1, 3, and 7 days after MI), indicating the activation of the TGF-{beta}1-TAK1-MKK3/6-p38 MAPK pathway." provenance.