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- _5 wasQuotedFrom 16914720 provenance.
- _5 value "The effects of IL-6 in ECs are mediated by interaction of sIL-6Ralpha/IL-6 complexes with gp130 dimers at the cell surface (30)......Importantly, similar inhibitory effects on STAT3 phosphorylation in response to sIL-6Ralpha/IL-6 were observed upon activation of endogenous G protein-coupled receptors for PGE2 (via EP2 and EP4 receptors), CGS21680 (A2A adenosine receptor [A2AAR]) and alphaMSH (melanocortin receptor 1), each of which are known to activate adenylyl cyclase and elevate cAMP (11, 14, 33, 44) (Fig. 1B)." provenance.