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- _2 wasQuotedFrom 16448517 provenance.
- _2 value "Superoxide anions are generated by means of single-electron reduction of molecular oxygen in complexes of the mitochondrial ETC (figure 1). Particularly, their production depends on the concentration of the intermediate metabolites of these complexes, and the ETC carriers in a more reduced state are capable of donating electrons to oxygen [7,20,22]. The reduced state of the ETC carriers can be achieved by an increased production of reducing equivalents in mitochondria or by a decreased electron transfer capability on (or after) these carriers [20-22]. Increase in cellular glucose uptake will lead to an increased production of reducing equivalents if metabolism is not inhibited, and this would then be accompanied by an increased concentration of electron donors for ETC." provenance.