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- _8 wasQuotedFrom 16170185 provenance.
- _8 value "Other antiapoptotic effects of C-Raf are mediated by a mitochondrial pool of the protein, which, on stimulation, localizes to the mitochondrial membrane where the protein interacts with and phosphorylates Bcl-2, Bcl-2–associated athanogene, and other pro-apoptotic regulators, abrogating their pro-apoptotic effects.157,167 The antiapoptotic effects of C-Raf are also mediated through the ankyrin-repeat protein Tvl-1 and apoptosis signal-regulated kinase-1.166,168,169" provenance.