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- _5 wasQuotedFrom 17034424 provenance.
- _5 value "The second, less well-studied pathway is thought to be limited to TLR3 and TLR4. TLR signalling via the adaptor molecules Toll/IL-1-receptor-domain-containing adaptor inducing IFN-? (TRIF) and TRIF-related adaptor molecule (TRAM) activates IRF-3 and IRF-7 and, ultimately, IFN-inducible genes such as IFN-?-inducible protein 10 (IP-10) and RANTES, via type I IFN production and autocrine activation of the JAK/STAT pathway" provenance.