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- _4 value "To determine whether PKA-induced PKB activation accounts for GSK-3 phosphorylation after treatment with 8-Br-cAMP, forskolin, or isoproterenol, PKB phosphorylation at serine 473 and threonine 308, which is crucial for activation of PKB (20), was assessed. As expected, insulin and IGF-1 strongly stimulated phosphorylation of PKB at serine 473 in NIH 3T3 or Rat1 cells (Fig. 2B). In contrast, 8-Br-cAMP, forskolin, and isoproterenol did not significantly alter PKB phosphorylation at serine 473 (Fig. 2B). Similar results were obtained with a threonine 308 phosphorylation-specific antibody (data not shown)." provenance.