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- _6 wasQuotedFrom 12648469 provenance.
- _6 value "Cytokine receptors are devoid of kinase activity and associate with Janus tyrosine kinases (Jak) to transduce signals. Growth hormone (GH) binding to its receptor activates Jak2, which has been shown to phosphorylate a specific tyrosine residue in the cytoplasmic domain of ErbB1. This residue serves as a docking site for Grb2, whose recruitment stimulates the MAPK pathway [43]." provenance.