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- _5 wasQuotedFrom 19749179 provenance.
- _5 value "Extending our prior reports that intravenous (IV) administration of the sphingolipid angiogenic factor, sphingosine 1-phosphate (S1P), attenuates inflammatory lung injury and vascular permeability via ligation of S1PR1, we now determine that direct intratracheal (IT) or intravenous (IV) administration of S1P, or a selective S1PR1 agonist (SEW- 2871), produces highly concentration-dependent barrier-regulatory responses in the murine lung. IT or IV administration of S1P or SEW-2871 at <0.3 mg/kg was protective against LPS-induced murine lung inflammation and permeability," provenance.