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- _7 wasQuotedFrom 17922028 provenance.
- _7 value "TSC2 S1798A mutant.Thi s mutant was used to prove that RSK-dependent phosphorylation of tuberin on Ser1798 inhibits its potential to turn off Rheb and to downregulate the activities of mTOR and p70S6K.Mu tation of Ser1798 inhibited most of tuberin phosphorylation and inactivation by RSK (Roux et al., 2004).Invest igating PARP cleavage, caspase 3 cleavage, the percentage of HOPI-positive cells and the percentage of subG1 cells demonstrated that the cell survival effects of activated Ras over tuberin-induced apoptosis are significantly diminished by this mutation in TSC2 (Figures 5a–c)." provenance.