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- _3 wasQuotedFrom 12223121 provenance.
- _3 value "In the meantime, the expression of SRC-2 mRNA was elevated in SRC-1 null mice, suggesting that SRC-2 can partially compensate for SRC-1 function SRC-3 is the most distinct among the three members. It coactivates not only the nuclear receptors, but also other unrelated transcription factors such as those in the cAMP or cytokine pathways [15]. Compared with the widespread expression of SRC-1 and SRC-2, expression of SRC-3 is restricted to the mammary gland and several other tissues [16]. Disruption of the SRC-3 gene in mice causes severe growth and reproductive defects, including the retardation of mammary gland development" provenance.