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- _7 wasQuotedFrom 11444530 provenance.
- _7 value "unlike other target genes of NFI, direct interaction of NFI with MT-I promoter is not necessary to mediate its repression. an NFI-C deletion mutant lacking the DNA binding domain continued to repress MT-I promoter. Overexpression of MTF-1, the key trails-acting factor involved in MT-I gene transcription, surmounted NFI-mediated repression of the basal and zinc-induced MT-I promoter activity. Interaction of NFI with another protein(s), probably MTF-I, may be involved in this repression." provenance.