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- _5 wasQuotedFrom 11139588 provenance.
- _5 value "PTEN and a catalytically inactive AKT decreased PI 3-kinase-induced [Estrogen-independent ESR1] activity, suggesting that PI 3-kinase utilizes AKT-dependent and AKT-independent pathways in activating ERalpha . The consensus AKT phosphorylation site Ser-167 of ERalpha is required for phosphorylation and activation by AKT." provenance.