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- _4 wasQuotedFrom 8621729 provenance.
- _4 value "Activation of the mitogen-activated protein kinase cascade is a critical event in mitogenic growth factor signal transduction. Mitogen-activated protein kinase is directly activated by a dual specific kinase. Activation of MEK1 requires the phosphorylation of serine residues 218 and 222. The a-Raf activated by serum stimulation induced activation of MEK1, which is determined by the coupled kinase activity, and immunoprecipitation and yeast-two hybrid analysis showed that MEK1 is direct substrate of a-Raf." provenance.