Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAcljSVf7ieS3Yi4Y2QAH9lZ57-_tCFWyFQBhG7_jV-1I#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 wasQuotedFrom 15070697 provenance.
- _4 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.