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- _5 value "Mitogenic indicators. The DNA content of the IGF and IGF+PD infused muscles increased ~50% compared with the contralateral muscles (Fig. 2A). The concentration of DNA was also increased by both treatments (Table 1). Similarly, there was a significant increase in the expression and/or accumulation of cyclin D1 mRNA in the IGF and IGF+PD muscles (Fig. 2B)." provenance.