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- _5 wasQuotedFrom 15021891 provenance.
- _5 value "b-catenin can be oncogenically activated not only by direct mutation but also by inactivation of APC. Alterations of the APC gene occur in 80% of the human colon cancers. In the absence of APC, b-catenin cannot be phosphorylated by Gsk3b, and it consequently accumulates and translocates into the nucleus" provenance.