Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAdeb6Gw4ZwWdLYlKQ40l93PdULrmnwkPuAmxuQBwfiGQ#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 wasQuotedFrom 11741970 provenance.
- _6 value "However, ectopic expression of RhoB, but not the closely related family member RhoA, resulted in a 5-fold decrease of T beta R-II promoter activity. Furthermore, ectopic expression of RhoB, but not RhoA, resulted in a significant decrease of T beta R-II protein expression and resistance of tumor cells to TGF-beta-mediated cell growth inhibition. Consequently, transcription assays using an AP1 reporter showed that AP1-mediated transcription is down-regulated by RhoB. Altogether, these results identify a mechanism by which RhoB antagonizes TGF-beta action through transcriptional down-regulation of AP1 in T beta R-II promoter." provenance.